Program
Timetable
President's Lecture
November 18 (Wed.) 16:20-16:40 Room A (2F Leo Esaki Main Convention Hall)
- ChairTakafumi Komori
- Biopharmaceutical Assessment, Deep Human Biology Learning, Eisai Co., Ltd.
- PLPharmacokinetics and ADME Science Today: The Future of JSSX
- SpeakerHiroyuki Kusuhara
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
Short Course/Annual Meeting Joint Distinguished Lecture
November 16 (Mon.) 17:30-18:30 Room A (2F Leo Esaki Main Convention Hall)
- ChairTakafumi Komori
- Biopharmaceutical Assessment, Deep Human Biology Learning, Eisai Co., Ltd.
- ChairRyoichi Saito
- Research Division, Chugai Pharmaceutical Co., Ltd.
- JDLIntegration of Molecular Simulation and Artificial Intelligence for Drug Molecule Discovery and Design (Tentative)
- SpeakerTakatsugu Hirokawa
- Division of Biomedical Science, Institute of Medicine, University of Tsukuba
Special Invited lecture 1
November 17 (Tue.) 13:00-14:00 Room A (2F Leo Esaki Main Convention Hall)
ISSX M&S – JSSX M&SP Collaborative Initiative ICH M15 in Action: Industrial Case Studies in Model-Informed Drug Development (MIDD)
- ChairChie Emoto
- Translational Research Division, Chugai Pharmaceutical Co., Ltd.
- ChairTeruki Hamada
- Translational Research Business Unit, Axcelead Drug Discovery Partners, Inc.
- SIL1-1The Road to Tsukuba: How ISSX and JSSX Got Here
- SpeakerChie Emoto
- Translational Research Division, Chugai Pharmaceutical Co., Ltd.
- SIL1-2Application of ICH M15 MIDD: Integrated Physiologically-based Pharmacokinetic (PBPK) Modeling Generated MIDD Evidence for Gastric Emptying Delay-Mediated Drug Interaction
- SpeakerJenny Y. Chien
- Eli Lilly and Company
Special Invited lecture 2
November 18 (Wed.) 13:40-14:40 Room A (2F Leo Esaki Main Convention Hall)
- ChairKazuhiro Tetsuka
- Translational & Biomedical Science, Astellas Pharma Inc.
- SIL2Microengineered mimicry of human health and disease
- SpeakerDan Huh
- University of Pennsylvania
Special Invited lecture 3
November 18 (Wed.) 16:40-17:10 Room A (2F Leo Esaki Main Convention Hall)
- ChairHiroshi Yamazaki
- Showa Pharmaceutical University
- SIL3Implications of CYP2J2 in drug-induced cardiac adverse effects
- SpeakerEric Chan
- Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore
Symposium 1 (Modeling & Systems Pharmacology DIS)
November 17 (Tue.) 9:30-11:30 Room A (2F Leo Esaki Main Convention Hall)
Cutting-Edge Research on Mechanistic Absorption Modeling
- ChairShinichi Kijima
- Pharmaceuticals and Medical Devices Agency
- ChairChie Emoto
- Translational Research Division, Chugai Pharmaceutical Co., Ltd.
- SY1-1Physiologically Based Biopharmaceutics Modeling (PBBM) Applications in Drug Development
- SpeakerTycho Heimbach
- Merck & Co., Inc.
- ChairSatoshi Nakayama
- DMPK Research Laboratories, Research Division, Tanabe Pharma Corporation
- ChairHiroyuki Sayama
- Modeling & Simulation, Early Development & Translational Science, Astellas Pharma Inc.
- SY1-2Prediction of negative food effects on oral drug absorption caused by adsorption to food
- SpeakerAyahisa Watanabe
- Laboratory for Medicinal Chemistry Research, Pharmaceutical Research Division, Shionogi & Co., Ltd.
- ChairYoshinobu Nakamaru
- Clinical Pharmacology Strategy, Clinical Development, R&D Japan, Bristol-Myers Squibb K.K.
- ChairTakashi Yoshikado
- Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy
- SY1-3PBBM Linking Formulation Properties and Oral Absorption
- SpeakerKazuki Matsui
- Pharmaceutical R&D, ONO Pharmaceutical Co., Ltd.
- ChairRyoko Sawamura
- Quantitative Clinical Pharmacology Department, Daiichi Sankyo Co., Ltd.
- ChairTsuyoshi Minematsu
- Formulation & ADME, Oncology Research, Astellas Pharma Inc.
- SY1-4A PBPK Framework for Naïve Predictions of Monoclonal Antibody Pharmacokinetics After Subcutaneous Administration
- SpeakerDonato Teutonico
- Pharmacometrics, Translational Medicine Unit, Sanofi, Vitry-sur- Seine, France
- Panel Discussion
- ChairYuki Iwaki
- Clinical Pharmacology & Pharmacometrics, Global R&D, Johnson & Johnson
- ChairTeruki Hamada
- Translational Research Business Unit, Axcelead Drug Discovery Partners, Inc.
Symposium 2 (Metabolism/Toxicity DIS-1)
November 17 (Tue.) 9:30-11:30 Room B (2F Convention Hall 200)
How to teach drug metabolism and pharmacokinetics: Bridging academic lectures, practical training, and industry education
- ChairSeigo Sanoh
- School of Pharmaceutical Sciences, Wakayama Medical University
- ChairKota Kato
- Applied Safety-JP, Applied Research & Nonclinical Safety, Early Development & Translational Science, Astellas Pharma Inc.
- SY2-1Drug metabolism education in schools of pharmacy and pharmaceutical sciences at Japanese universities
- SpeakerKouichi Yoshinari
- Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
- SY2-2Education and Research on Species Differences in Drug Metabolism and Pharmacokinetics
- SpeakerShouta Nakayama
- Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University
- SY2-3Developing Pharmacokinetic Scientists in the Pharmaceutical Industry: Current Status and Future Outlook
- SpeakerSatoshi Kitamura
- Applied Research & Nonclinical Safety, Early Development & Translational Science, Astellas Pharma Inc.
- SY2-4Researcher Training Programs at Shin Nippon Biomedical Laboratories(SNBL) — From Newcomers to Veterans
- SpeakerKazuhiro Nishimiya
- Study Support Unit, Bioanalysis Dept., Drug Safety Reserch Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
- Panel Discussion
Symposium 3 (DDS DIS)
November 17 (Tue.) 9:30-11:30 Room E (1F Conference Room 102)
Frontiers in DDS research Opening New Avenues for the treatment of CNS Disorders
- ChairTakanori Kanazawa
- Graduate School of Biomedical Sciences, Tokushima University
- ChairHidefumi Mukai
- Department of Pharmaceutical Informatics, Graduate School of Biomedical Sciences, Nagasaki University
- SY3-1Pharmacokinetic Evaluation of Nose-to-Brain Drug Delivery via Intranasal Administration for Central Nervous System Disorders
- SpeakerAkiko Tanaka
- Department of Pharmaceutical Technology, Kobe Pharmaceutical University
- SY3-2Development of a Brain-Targeted Drug Delivery System Based on Ultrasound and Microbubbles
- SpeakerDaiki Omata
- Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
- SY3-3Hippocampal neuron-targeted delivery of biological drugs for dementia therapy
- SpeakerNoriyasu Kamei
- Laboratory of Drug Delivery Systems, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
- SY3-4New targeted DDS strategy for overcoming neuroimmune diseases
- SpeakerKosuke Shimizu
- Nanotheranostics Laboratory, Institute of Photonics Medicine, Hamamatsu University School of Medicine
- SY3-5Dynamic nanomedicines for brain targeting
- SpeakerKanjiro Miyata
- Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo
Symposium 4 (Dynamic education and cross-disciplinary DIS)
November 17 (Tue.) 14:15-16:45 Room B (2F Convention Hall 200)
Basic course of pharmacokinetics on cross-disciplinary
- ChairSeigo Sanoh
- School of Pharmaceutical Sciences, Wakayama Medical University
- ChairTomomi Furihata
- Laboratory of Advanced Drug Development Sciences, Tokyo University of Pharmacy and Life Sciences
- SY4-1Utilizing human intestinal cells for the prediction of the risk of drug-induced intestinal toxicity
- SpeakerKazuya Maeda
- Laboratory of Pharmaceutics, School of Pharmacy, Kitasato University
- SY4-2Fundamentals and Future Directions of Physiologically Based Biopharmaceutics Modeling
- SpeakerAtsushi Kambayashi
- Faculty of Pharmaceutical Sciences, Tokyo University of Science
- SY4-3Prediction of volume of distribution using in silico physicochemical and experimental binding parameters
- SpeakerToshiki Arai
- Drug Metabolism and Pharmacokinetics Research Department, Nippon Shinyaku Co., Ltd.
- SY4-4Fundamentals and applications of cell-based assays using iPS cell-derived cells
- SpeakerHiroshi Kato
- Bioanalytical Sciences Research Department, Toyama Reserch and Development Center, FUJIFILM Toyama Chemical Co., Ltd.
- SY4-5Applications of immuno-affinity LC–MS for ADC bioanalysis and ADME in drug discovery
- SpeakerToshiko Yahata
- Formulation & ADME, Oncology Research, Astellas Pharma Inc.
Symposium 5 (Analysis & Imaging DIS)
November 17 (Tue.) 14:15-16:45 Room E (1F Conference Room 102)
Spatial Omics Driving the Next Generation of Pharmacokinetics ― A New Paradigm in Spatially Resolved Pharmacokinetics ―
- ChairYukari Tanaka
- DMPK and Analytical Sciences 4 group, Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd.
- ChairMasamitsu Maekawa
- Department of Pharmaceutical Sciences, Tohoku University Hospital
- SY5-1Pathology-Informed Perspectives on Cancer Spatial Analysis: Multiplex Immunohistochemistry and Spatial Transcriptomics
- SpeakerMaki Kobayashi
- Translational pathology group (Group V), Translational Laboratories II, Precision Medicine Function, Daiichi Sankyo Co., Ltd.
- SY5-2Development of AI-Assisted Proteomics for Pathology Specimens
- SpeakerYasuo Uchida
- Laboratory of Molecular Systems Pharmaceutics, Graduate School of Biomedical and Health Sciences, Hiroshima University
- SY5-3Elementomics analysis and PET/SPECT metallomics-driven drug discovery research
- SpeakerHiroyuki Yasui
- Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University
- SY5-4Exploration of prognostic markers for renal function decline by spatial transcriptome analysis
- SpeakerKazuhiro Morishita
- Biological Technology Dept., Research Division, Chugai Pharmaceutical Co., Ltd.
- SY5-5Spatial lipidomics to illuminate the lipidome signatures associated with biology and disease
- SpeakerMakoto Arita
- Faculty of Pharmacy, Keio University/RIKEN-IMS
Symposium 6 (Regulation DIS)
November 18 (Wed.) 9:30-12:00 Room A (2F Leo Esaki Main Convention Hall)
Current and Future Regulation on New Approach Methodologies
- ChairSatoshi Kitamura
- Applied Research & Nonclinical Safety, Early Development & Translational Science, Astellas Pharma Inc.
- ChairYoshiro Saito
- National Institute of Health Sciences
- SY6-1International Trends in NAMs for Nonclinical Evaluation and PMDA Initiatives to Promote the 3Rs
- SpeakerFumito Mikashima
- Pharmaceuticals and Medical Devices Agency
- SY6-2Drug Development Tool Qualification and Integration at FDA: Innovative Science and Technology Approach for New Drugs (ISTAND) Program
- SpeakerYork Tomita
- CDER-Office of New Drugs, US FDA
- SY6-3Current trends and challenges in the use of NAMs for the nonclinical evaluation of therapeutic monoclonal antibodies
- SpeakerAkiko Ishii-Watabe
- Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
- SY6-4Exploring the Boundaries of NAMs in DMPK Research for Antibody Drug Development
- SpeakerMiho Nagayasu
- Translational Research Division, Chugai Pharmaceutical Co., Ltd.
- SY6-5Standardization and regulatory initiatives of gut-liver Microphysiological Systems (MPS) for OECD Test Guideline development
- SpeakerSeiichi Ishida
- Graduate School of Engineering, Sojo University
Symposium 7
(AI/Machine Learning for Pharmacokinetic Prediction DIS)
November 18 (Wed.) 9:30-12:00 Room B (2F Convention Hall 200)
DMPK Meets the AI/ML Frontier: A Gateway Through M&S and DDI
- SY7-1Progress Report on DIS AI/ML-based PK Prediction
- SpeakerYohei Kosugi
- Drug Metabolism, Pharmacokinetics and Modeling, Preclinical and Translational Sciences, Takeda Pharmaceutical Company Limited
- ChairKoichi Handa
- Pharmacokinetics Laboratory, Non-clinical Development Department, Research & Development Division, Meiji Seika Pharma, Co., Ltd.
- ChairHiroaki Iwata
- Faculty of Medicine, Tottori University
- SY7-2Applying Machine Learning to PBPK Models: Significance and Practical Challenges in DMPK Research
- SpeakerShinji Nakayama
- DMPK Research Laboratories, Research Division, Tanabe Pharma Corporation
- SY7-3Prediction of Pharmacokinetic Parameters by Machine Learning Utilizing Biomimetic Chromatography
- SpeakerHideaki Mamada
- DMPK Research Laboratories, Central Pharmaceutical Research Institute, Shionogi &Co., Ltd.
- SY7-4OrchestRA: Democratizing Data-Driven Drug Discovery with an Autonomous Multi-AI Agent System
- SpeakerKazuki Nakanishi
- Department of AI Systems Medicine, M&D Data Science Center, Institute of Integrated Research, Institute of Science Tokyo
- SpeakerHideyuki Shimizu
- Graduate School of Medical and Dental Sciences, Institute of Science Tokyo
- ChairTadahaya Mizuno
- Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- ChairYohei Kosugi
- Drug Metabolism, Pharmacokinetics and Modeling, Preclinical and Translational Sciences, Takeda Pharmaceutical Company Limited
- SY7-5Initiatives in Drug Discovery AI/ML at Daiichi Sankyo
- SpeakerShotaro Maedera
- Data Intelligence CoE, Global DX, Daiichi Sankyo Co., Ltd.
- SY7-6AI for Drug Discovery in Practice
- SpeakerHiroshi Kajino
- Digital Unit, Axcelead Drug Discovery Partners, Inc.
- Panel Discussion
Symposium 8 (New modality DIS)
November 18 (Wed.) 9:30-11:30 Room E (1F Conference Room 102)
Advances in Quantitative Technologies for New Modalities
- ChairYoshiteru Kamiyama
- Applied research and non-clinical safety, Applied Drug Metabolism and Pharmacokinetics, Astellas Pharma Inc.
- ChairYoichi Naritomi
- Kobe Research Institute, HEALIOS K.K.
- SY8-1From GalNAc to Beyond the Liver: Clinical Implementation of RNAi Delivery and Expansion of Target Tissues
- SpeakerSoichiro Matsushima
- Development Japan, Alnylam Japan K.K.
- SY8-2Practical considerations for the evaluation of pharmacokinetics and biodistribution of locally administered mRNA-LNP therapeutics: case study
- SpeakerAkihiro Matsumoto
- Applied Research & Nonclinical Safety, Early Development & Translational Sciences, Astellas Pharma Inc.
- SY8-3Considerations and Strategies for Biodistribution Assessment of Induced Pluripotent Stem Cell-derived Cell Therapy Products: A Case Study with Pancreatic Islet Cells
- SpeakerMiyu Nakayama
- Drug Metabolism & Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited
- SY8-4Development of quantitative methods and characterization of in vivo pharmacokinetics of AKT-01/HLCN061, gene engineered human induced pluripotent stem cell-derived natural killer cells
- SpeakerYoichi Naritomi
- Kobe Research Institute, HEALIOS K.K.
Symposium 9 (Transporter DIS)
November 19 (Thu.) 9:30-12:00 Room A (2F Leo Esaki Main Convention Hall)
Diverse Approaches to Unraveling Transporter Functions
- ChairTomoya Yasujima
- Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University
- ChairSaki Noguchi
- Division of Pharmaceutics, Faculty of Pharmacy, Keio University
- SY9-1Hidden Physiology of Transporters through a Multiscale Approach
- SpeakerShushi Nagamori
- Division of Multiscale Nutritional Biochemistry, Research Center for Medical Sciences, The Jikei University School of Medicine
- SY9-2Development of Microphysiological Systems (MPS) Targeting Renal Proximal Tubule Transporters and Their Application to Drug Discovery
- SpeakerRyuji Yokokawa
- Department of Micro Engineering, Graduate School of Engineering, Kyoto University
- SY9-3Species-Specific Expression and Localization of Placental Transporters and Their Influence on Fetal Drug Transfer
- SpeakerMasatoshi Tomi
- Division of Pharmaceutics, Faculty of Pharmacy, Keio University
- SY9-4Drug repositioning targeting organic cation transporter 2 based on integrated analysis of machine learning and medical big data
- SpeakerKenji Ikemura
- Department of Pharmacy, The University of Osaka Hospital
- SY9-5Identification and functional analysis of the sperm sodium/proton exchanger SLC9C1 complex through reverse genetics and coevolutionary analysis
- SpeakerRie Iida
- Immunology Frontier Research Center, The University of Osaka／Research Institute for Microbial Diseases, The University of Osaka
- SY9-6Hepatic OATP1Bs as Conformationally Dynamic Molecular Machines: Integrating Pharmacokinetic Evidence with Structural Insights
- SpeakerShen Ling
- ShanghaiTech University
Symposium 10 (Metabolism/Toxicity DIS-2)
November 19 (Thu.) 9:30-11:30 Room B (2F Convention Hall 200)
The future of drug metabolism and toxicology: Insights from emerging researchers
- ChairKousei Ito
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
- ChairTatsuki Fukami
- Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University
- SY10-1Transcriptional regulation of enzymes involved in drug response: roles of G-quadruplex structures and coordinated expression with transporters
- SpeakerChieri Fujino
- Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University
- SY10-2Impact of oxygen environment control on hepatocyte functions in culture models — Improved hypoxia, enhanced drug metabolism, and induction of zonation-like phenotypes —
- SpeakerNaoki Takaoka
- Laboratory of Pharmaceutical Health Science, School of Pharmaceutical Sciences, Wakayama Medical University
- SY10-3Pharmacokinetic study with highly humanized animal models
- SpeakerGenki Minegishi
- Department of Biopharmaceutics, Graduate School of Clinical Pharmacy, Meiji Pharmaceutical University
- SY10-4Integrated Experimental and Data-Based Analysis of Immune Responses in Therapeutic Antibody Efficacy and Safety
- SpeakerYuta Tamemoto
- Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University
- SY10-5Exploration of Endogenous Biomarkers for the Early Detection of Drug-Induced Liver Injury
- SpeakerMasaki Kumondai
- Department of Pharmaceutical Sciences, Tohoku University Hospital
Symposium 11 (Microphysiological system and iPS DIS)
November 19 (Thu.) 9:30-11:30 Room D (1F Conference Room 101)
Next generation microrheological systems, models, and their application
- ChairKengo Watanabe
- Daiichi Sankyo Co., Ltd.
- ChairSeiichi Ishida
- Biotechnology and Life Science, Sojo University
- SY11-1A Novel Evaluation Strategy for Drug-Induced Kidney Injury Incorporating Hepatic Metabolism: Toward Understanding Inter-Organ Crosstalk
- SpeakerHiroshi Arakawa
- Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University
- SY11-2Recapitulating the human blood–brain barrier: Science, Models, and Challenges
- SpeakerMasanori Tachikawa
- Laboratory of Theoretical Chemistry for Drug Discovery, Graduate School of Biomedical Sciences, Tokushima University
- SY11-3Development and Commercialization Strategy of a Proximal Tubule MPS for Recapitulating Drug Transporter Function
- SpeakerYoshikazu Kameda
- R&D department, Physios Biotech, Inc.
- SY11-4Pharmaceutical industry views on next-generation MPS for pharmacology and safety evaluations in drug discovery and future directions
- SpeakerMaho Okubo
- Translational & Biomedical Science, Astellas Pharma Inc.
Symposium 12 (In vivo models DIS)
November 19 (Thu.) 13:30-15:30 Room B (2F Convention Hall 200)
Frontiers of in vivo Models Across Diverse Therapeutic Modalities: From Small Molecules to Regenerative Medicine
- ChairKaoru Kobayashi
- Laboratory of Biopharmaceutics, Meiji Pharmaceutical University
- ChairSyunsuke Yamamoto
- Discovery Biologics Dept., Chugai Pharmaceutical Co., Ltd.
- SY12-1Newt super-regeneration: the fibrosis-to-regeneration switch
- SpeakerChikafumi Chiba
- Institute of Life and Environmental Sciences, University of Tsukuba
- SY12-2Development of Hepatic POR-Deficient Liver-Humanized Mouse Model for Human Drug Metabolism and Pharmacokinetics
- SpeakerHiroshi Suemizu
- Biomedical Research Division, Central Institute for Experimental Medicine and Life Science
- SY12-3Development of a method for predicting human pharmacokinetics of targeted protein degraders using chimeric mice with humanized livers
- SpeakerWeilin Shen
- DMPK Research Laboratories, Research Division, Tanabe Pharma Corporation
- SY12-4Translational Pharmacokinetic Prediction of FcRn-Engineered Antibodies Using Human FcRn Transgenic Mouse Models
- SpeakerKenta Haraya
- Discovery Biologics Dept., Research Division, Chugai Pharmaceutical Co., Ltd.
- SY12-5Key considerations in biodistribution evaluation of gene therapy products using adeno-associated virus vectors
- SpeakerMiyu Nakayama
- Drug Metabolism & Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited
Symposium 13 (Efficacy and Safety DIS)
November 19 (Thu.) 13:30-15:30 Room D (1F Conference Room 101)
Frontiers in Metabolism, Adverse Effects, and Toxicity Research for Next-Generation Drug Development
- ChairMakoto Yamazaki
- DMPK Research Laboratories, Research Division, Tanabe Pharma Corporation
- ChairYuki Kishino
- Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd.
- ChairMasanori Tachikawa
- Laboratory of Theoretical Chemistry for Drug Discovery, Graduate School of Biomedical Sciences, Tokushima University
- SY13-1Toward the Control of Refractory Inflammatory Diseases Using SPREDs
- SpeakerAi Kotani
- Research Institute for Microbial Diseases, The University of Osaka
- SY13-2Natural language processing–based extraction of adverse events from real-world text and its applications
- SpeakerSatoko Hori
- Division of Drug Informatics, Keio University Faculty of Pharmacy
- SY13-3Nonclinical Models for Understanding DXd ADC-Related Interstitial Lung Disease: Current Status and Future Perspectives
- SpeakerKazuyoshi Kumagai
- Medicinal Safety, Daiichi Sankyo Inc.
- SY13-4Comparative study of acute CNS toxicity in rodents and non-human primates administered with centrally delivered antisense oligonucleotides
- SpeakerHironobu Nishina
- Safety Research Laboratories, Research Division, Tanabe Pharma Corporation
- SY13-5Reconsidering the role of HLA in idiosyncratic drug toxicity
- SpeakerShigeki Aoki
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Symposium 14 (Absorption DIS)
November 19 (Thu.) 13:30-15:30 Room E (1F Conference Room 102)
Absorption Research EXPO2026: Romance and Adventure in Oral Absorption of Middle-to-Large Molecule Drugs
- ChairYoshiyuki Shirasaka
- Laboratory of Pharmaceutics, Showa Pharmaceutical University
- ChairToshimichi Nakamura
- Formulation & ADME, Oncology Research, Astellas Pharma Inc.
- SY14-1Beyond Injection: Toward quantitative prediction of oral absorption of mid-size peptides based on phenomena, mechanisms, and kinetics
- SpeakerYoshiyuki Shirasaka
- Laboratory of Pharmaceutics, Showa Pharmaceutical University
- SY14-2Development and In Silico Validation of a Novel Method for Evaluating the Oral Absorption of P-gp Substrate Macrocyclic Peptides
- SpeakerRyo Tamura
- Pharmaceutical Science Dept., Translational Research Division, Chugai Pharmaceutical Co., Ltd.
- SY14-3Oral formulation strategies for medium-size drugs: From the perspective of physicochemical properties
- SpeakerKunikazu Moribe
- Laboratory of Pharmaceutical Technology, Graduate School of Pharmaceutical Sciences, Chiba University
- SY14-4Formulation and kinetic research for oral mid-size molecule in drug discovery
- SpeakerTakashi Nozawa
- Formulation & ADME, Oncology Research, Astellas Pharma Inc.
- Panel Discussion
JSSX Special Symposium
November 17 (Tue.) 14:15-17:15 Room A (2F Leo Esaki Main Convention Hall)
Advances in DDI evaluations: Recent Trends from Pre-clinical Studies to Regulatory Submissions
- ChairChie Emoto
- Translational Research Division, Chugai Pharmaceutical Co., Ltd.
- ChairR. Scott Obach（Pfizer, Inc.）
- SSY-1Special Issue Overview: Advances in DDI Evaluation - Perspectives and Case Studies Across Academia, Industry, and Regulators-
- SpeakerChie Emoto
- Translational Research Division, Chugai Pharmaceutical Co., Ltd.
- SSY-2Latest Improvements for In Vitro Metabolism Studies to Address Drug-Drug Interactions
- SpeakerR. Scott Obach
- Pfizer, Inc.
- SSY-3Clinical translatability of humanized liver chimeric mouse models for pharmacokinetic drug-drug interactions
- SpeakerHaruka Tsutsui
- Pharmaceutical Science Dept., Chugai Pharmaceutical Co., Ltd.
- SSY-4UDP-Glucuronosyl transferase mediated drug-drug interactions: An Industry perspective on recommended in vitro studies
- SpeakerDavid M. Stresser
- Quantitative, Translational & ADME Sciences/QTAS, AbbVie Inc.
- SSY-5Lessons learned from using coproporphyrin-I for regulatory submission: insights from the ensitrelvir case and beyond
- SpeakerRyosuke Watari
- Laboratory for Drug Discovery and Development, Shionogi & Co., Ltd.
- SSY-6Advances and challenges for drug interaction evaluation - Perspectives on the ICH M12 guideline
- SpeakerYuya Suzuki
- Office of New Drug IV, Pharmaceuticals and Medical Devices Agency
- SSY-7Managing Implementation of Next Generation MIDD: Integration via Model Master File
- SpeakerAmin Rostami-Hodjegan
- University of Manchester & Certara Inc, UK
Organizering Committee Symposium
November 19 (Thu.) 13:30-15:30 Room A (2F Leo Esaki Main Convention Hall)
The Cutting Edge of Human Prediction and Risk Assessment in ADMET Sciences: Challenging by Nonclinical Approaches and Methodologies
- ChairTakafumi Komori
- Biopharmaceutical Assessment, Deep Human Biology Learning, Eisai Co., Ltd.
- ChairToru Usui
- Preclinical Research Unit, Sumitomo Pharma Co., Ltd.
- OSY-1Harnessing Human Cell-Based In Vitro Assays for the Evaluation of Organ Toxicity
- SpeakerTomoya Sameshima
- Nonclinical Safety and Pharmacology, Research, Takeda Pharmaceutical Company Limited
- OSY-2Human Ex Vivo Models for Translational Safety Assessment: Mechanistic Insights Toward Human Toxicity Prediction
- SpeakerFoivos-Filippos Tsokanos
- Pharmacokinetics and Pharmacodynamics Research Laboratories, Daiichi Sankyo Co. Ltd.
- OSY-3Drug Metabolism and Drug-Induced Organ Toxicity in Humanized-Liver TK-NOG Mice
- SpeakerShotaro Uehara
- Department of Research for Humanized Model, Central Institute for Experimental Medicine and Life Science
- OSY-4Small Intestinal Stem Cell–Derived In Vitro Models for Predicting Drug Absorption and Gastrointestinal Toxicity in Humans
- SpeakerHiroyuki Kusuhara
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
Asia Joint Symposium
November 18 (Wed.) 9:30-12:00 Room D (1F Conference Room 101)
- ChairKazuya Maeda
- Laboratory of Pharmaceutics, School of Pharmacy, Kitasato University
- ChairYoung-Hee Choi
- College of the Pharmacy, Dongguk University
- ASY-1Targeting KRAS Oncogenic Addiction in Cholangiocarcinoma
- SpeakerSiwanon Jirawatnotai
- Department of Pharmacology and Center of Research Excellence for Precision Medicine and Systems Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
- ASY-2An Integrated PK/PD Strategy for Tissue Distribution-Driven Discovery of PD Target Organs in Natural Products
- SpeakerYoung-Hee Choi
- College of the Pharmacy, Dongguk University
- ASY-3Exposure, Effect, and Selectivity: Integrated LC–MS/MS Platforms for PK–PD and Proteomic Profiling of Protein Degraders
- SpeakerShashyendra Singh Gautam
- Biocon Bristol Myers Squibb Research & Development Center
- ASY-4Industry perspective for evaluating CYP450 Induction: Challenges and Solutions in PCC/IND/NDA
- SpeakerZhuohan Hu
- Research Institute for Liver Diseases (Shanghai) Co. Ltd., Chinese Industry Society for Study of Xenobiotics (CBIITA-SSX)
- ASY-5Animal models for understanding the pathogenesis of idiosyncratic drug toxicity
- SpeakerShigeki Aoki
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
The Predoctoral Researcher-Initiative Session (PRIS) 2026
November 19 (Thu.) 9:30-12:00 Room E (1F Conference Room 102)
The Frontier of Pharmacokinetics pioneered by Young Scientists
- ChairYohei Ohto
- Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- ChairKeiichiro Nakamura
- Laboratory of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kitasato University
- ChairShogo Yasuda
- Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University
- PSY-ELInvestigation of the role of mucin in drug absorption and its molecular basis
- SpeakerHisanao Kishimoto
- Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
- PSY-1Model-Dependent Variation in Pharmacokinetics after Intraperitoneal Administration in Peritoneal Dissemination Mouse Models
- SpeakerMisaki Ishida
- Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University
- PSY-2Systematic Detection of Drug Interactions Involving Inhibition of CYP3A Using Adverse Event Reporting Database
- SpeakerHana Kumemura
- Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
- PSY-3Elucidating Organ Crosstalk Mediated by OAT2/SLC22A7
- SpeakerKeisuke Sato
- Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Tokyo University of Pharmacy and Life Sciences
- PSY-4Impaired induction of absorptive epithelial functions by DS-9300 and its species differences: Gastrointestinal toxicity evaluation using animal and human small intestinal organoids
- SpeakerMana Namai
- Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- PSY-5Improved prediction of human BCRP-mediated biliary clearance by incorporating hepatic cytosolic protein effects into relative expression factor approach
- SpeakerShotaro Yoshino
- Laboratory of Molecular Pharmacotherapeutics, Faculty of Pharmacy, Kanazawa University
Luncheon Seminar 1Sponsored by Central Institute for
Experimental Medicine and Life Science
November 17 (Tue.) 11:45-12:45 Room A (2F Leo Esaki Main Convention Hall)
HepaSH — From Experimental Human Hepatocytes to a Drug Discovery Tool
- ChairHiroshi Suemizu
Biomedical Research Division, Central Institute for Experimental Medicine and Life Science - LS1-1The Role of Hepatocytes as a Drug Discovery Tool (From the Perspective of Pharmaceutical Companies)
- SpeakerHiroshi Suemizu
Biomedical Research Division, Central Institute for Experimental Medicine and Life Science - LS1-2Future Research on Human Hepatocyte / HepaSH Cell
- SpeakerShotaro Uehara
Department of Research for Humanized Model, Central Institute for Experimental Medicine and Life Science
Luncheon Seminar 2Sponsored by SCIEX
November 17 (Tue.) 11:45-12:45 Room B (2F Convention Hall 200)
- ModeratorNaokazu Okamoto
SCIEX, Marketing & Market Development - LS2Expectations for EAD Fragment Analysis in the Structural Determination of Drug Metabolites
- SpeakerMotohiko Morihara
Bioanalysis Group I, Safety & Pharmacokinetic Research, Ono Pharmaceutical Co., Ltd.
Luncheon Seminar 3Sponsored by Leica Microsystems K.K.
November 17 (Tue.) 11:45-12:45 Room D (1F Conference Room 101)
To The Future of Microscopy Imaging
- ChairShintaro Tanaka
Leica Microsystems K.K. - LS3-1Micro-PK/PD Analysis Using Multimodal Imaging — Connecting drug distribution and pharmacological effects through image analysis —
- SpeakerMiyu Nakayama
Drug Metabolism & Pharmacokinetics Research Laboratories, Takeda Pharmaceutical Company Limited - LS3-2Multiscale Imaging Solutions for Drug Discovery Proof-of-Concept Studies, From Intracellular DDS Visualization at Super-Resolution to High-Speed 3D Live Imaging of Organoids-Introducing the STELLARIS Super-Resolution Confocal Microscope and Viventis SCAPE Light-Sheet Microscope software, AIVIA.
- SpeakerToshiyuki Hatano
Life science research, Leica Microsystems K.K.
Luncheon Seminar 4Sponsored by Miltenyi Biotec K.K.
November 17 (Tue.) 11:45-12:45 Room E (1F Conference Room 102)
- ModeratorMoritaka Nakamura
Miltenyi Biotec K.K. - LS43D Imaging-Based Pharmacokinetic evaluation in Drug Development: Toward Semi-Quantitative Approaches for PK/PD Analysis
- SpeakerSatomi Kanki
DAIICHI SANKYO COMPANY LIMITED, Research Function Pharmacokinetics and Pharmacodynamics Research Laboratories Group VI
Luncheon Seminar 5Sponsored by SEKISUI MEDICAL CO., LTD.
November 18 (Wed.) 12:20-13:20 Room A (2F Leo Esaki Main Convention Hall)
- ModeratorsAkio Kawamura
SEKISUI MEDICAL CO., LTD. - Satoshi Itou
Drug Development Solutions Center, SEKISUI MEDICAL CO., LTD. - LS5Let's enjoy together !
As Modalities Grow More Complex, What's Next for Pharmacokinetic Scientists?
Featuring the Latest Advances in Next-Generation ADCs - PanelistsMasayo Oishi
Translational & Biomedical Science, Early Development & Translational Science, Astellas Pharma Inc. - Shingo Sakamoto
DMPK & Analytical Sciences Laboratory for Drug Discovery and Development, Drug Discovery Research Division, Shionogi & Co., Ltd. - Tsuneo Deguchi
Research Laboratories Group III, Pharmacokinetics and Pharmacodynamics, Daiichi Sankyo Co., Ltd. - Toshiki Mochizuki
Global Drug Metabolism and Pharmacokinetics, Biopharmaceutical Assessment, Deep Human Biology Learning, Eisai Co., Ltd. - Miho Nagayasu
Non-clinical DMPK Group, Pharmaceutical Science Dept., Translational Research Div., Chugai Pharmaceutical Co., Ltd.
Luncheon Seminar 6Sponsored by Mitsui Chemicals, Inc.
November 18 (Wed.) 12:20-13:20 Room B (2F Convention Hall 200)
Recreating the Human Liver in vitro | Mitsui Chemicals × InSphero Luncheon Seminar The Latest Advances in Next-Generation ADMET and DILI Evaluation
- ChairSeiichi Ishida
Faculty of Biotechnology and Life Sciences, Graduate School of Engineering, Department of Biotechnology and Life Sciences, Sojo University - LS6-1Benchmarking Drug Induced Liver Injury in 3D Primary Human Liver Spheroids: A 152 Compound Study
- SpeakerJan Lichtenberg
InSphero AG - LS6-2Enhancement of Insert-Based Co culture and Bile Canaliculi Formation Using InnoCell®
- SpeakerYuji Komizu
Faculty of Biotechnology and Life Sciences, Department of Biotechnology and Life Sciences, Sojo University
Luncheon Seminar 7Sponsored by Bruker Japan K.K.
November 18 (Wed.) 12:20-13:20 Room D (1F Conference Room 101)
- ChairTaro Igarashi
Daltonics division, Bruker Japan K.K. - LS7Next-Generation Drug Metabolism and Pharmacokinetics Research enabled by Bruker High-Depth Multi-Omics Mass Spectrometry Platform
—Integrated Analysis using Proteomics, Metabolomics, and Mass Spectrometry Imaging— - SpeakerSatoshi Oshiro
Daltonics division, Bruker Japan K.K.
Luncheon Seminar 8Sponsored by Nihon Waters K.K.
November 18 (Wed.) 12:20-13:20 Room E (1F Conference Room 102)
- ChairMamiko Imaoku
Nihon Waters K.K. - LS8Frontiers in Bioanalysis for the Era of New Modalities
— High-Sensitivity Analysis Using Microflow and Ensuring Data Reliability — - SpeakerMotoji Oshikata
Nihon Waters K.K.
Luncheon Seminar 9Sponsored by SHIN NIPPON BIOMEDICAL LABORATORIES, LTD.
November 19 (Thu.) 12:15-13:15 Room B (2F Convention Hall 200)
- ChairYoshiaki Suwa
Shin Nippon Biomedical Laboratories, Ltd. - LS9Engineering Human ADME Prediction: An MPS Developer’s Approach
- SpeakerHiroshi Kimura
Micro/Nano Technology Center, Tokai University
Luncheon Seminar 10Sponsored by Labcorp Laboratories Japan G.K.
November 19 (Thu.) 12:15-13:15 Room D (1F Conference Room 101)
- ChairHitoshi Yamamura
Early Development, Labcorp Laboratories Japan GK - LS10Non-clinical and clinical radioactive ADME in the era of cAMS
- SpeakerDon McKenzie
Global Metabolism & CPC, Labcorp Laboratories Japan GK